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Browse InterEvol database

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  • Chain homologs for every chain in other complexes
  • Structural interologs for every interface
  • Retrieve interface structures, superimposed interologs structures and pre-computed sequence alignments in diverse species
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1. Protein-protein complex selection
You can select a complex from its PDB code or, if you don't know it, enter any word found in the title or the molecule name and select the PDB code of interest from the proposed list. For example: 2c35, 1q40 or proteasome

 PDB code or keyword :  

pdb IDKeywords
1fnt1fnt CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST IN COMPLEX WITH THE PROTEASOME ACTIVATOR PA26 FROM TRYPANOSOME BRUCEI AT 3.2 ANGSTROMS RESOLUTION HYDROLASE/HYDROLASE ACTIVATOR MULTICATALYTIC PROTEINASE, 20S PROTEASOME, PROTEIN DEGRADATION, ANTIGEN PROCESSING, PROTEASE, PROTEASOME ACTIVATOR, CELL ADHESION, INTERFERON INDUCTION, HYDROLASE/HYDROLASE ACTIVATOR COMPLEX PROTEASOME COMPONENT C11,PROTEASOME COMPONENT PRE2,PROTEASOME COMPONENT PRE3,PROTEASOME COMPONENT PRE4,PROTEASOME COMPONENT Y13,PROTEASOME COMPONENT PRE6,PROTEASOME COMPONENT Y7,PROTEASOME COMPONENT C5,PROTEASOME COMPONENT C1,PROTEASOME COMPONENT C7-ALPHA,PROTEASOME COMPONENT PUP1,PROTEASOME COMPONENT PUP2,PROTEASOME COMPONENT PUP3,PROTEASOME ACTIVATOR PROTEIN PA26,PROTEASOME COMPONENT PRE5
1iru1iru Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution HYDROLASE 20S proteasome, cell cycle, Immune response, proteolysis, ubiquitin, HYDROLASE 20S proteasome
1j2p1j2p alpha-ring from the proteasome from archaeoglobus fulgidus hydrolase proteasome, alpha-ring, hydrolase Proteasome alpha subunit
1j2q1j2q 20S proteasome in complex with calpain-Inhibitor I from archaeoglobus fulgidus hydrolase proteasome, ubiquitin, 20S, CP, hydrolase Proteasome alpha subunit,Proteasome beta subunit
1k321k32 Crystal structure of the tricorn protease HYDROLASE protein degradation, substrate gating, serine protease, beta propeller, proteasome, HYDROLASE tricorn protease
1p9d1p9d High-resolution structure of the complex of HHR23A ubiquitin-like domain and the C-terminal ubiquitin-interacting motif of proteasome subunit S5a REPLICATION protein-peptide complex, REPLICATION UV excision repair protein RAD23 homolog A,26S proteasome non-ATPase regulatory subunit 4
1pma1pma PROTEASOME FROM THERMOPLASMA ACIDOPHILUM PROTEASE PROTEASE, PROTEASOME, HYDROLASE PROTEASOME
1q5q1q5q The Rhodococcus 20S proteasome HYDROLASE proteasome assembly, pro-peptide, inter-subunit contacts, Rhodococcus erythropolis, HYDROLASE proteasome alpha-type subunit 1,proteasome beta-type subunit 1
1ryp1ryp CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST AT 2.4 ANGSTROMS RESOLUTION MULTICATALYTIC PROTEINASE MULTICATALYTIC PROTEINASE, 20S PROTEASOME, PROTEIN DEGRADATION, ANTIGEN PROCESSING, HYDROLASE, PROTEASE 20S PROTEASOME
1yar1yar Structure of Archeabacterial 20S proteasome mutant D9S- PA26 complex HYDROLASE/HYDROLASE ACTIVATOR proteasome 20S, PA26 proteasome activator 11S, HYDROLASE/HYDROLASE ACTIVATOR COMPLEX Proteasome alpha subunit,Proteasome beta subunit,proteasome activator protein PA26
1yx51yx5 Solution Structure of S5a UIM-1/Ubiquitin Complex HYDROLASE NMR, polyubiquitin, proteasome, S5a, UIM, HYDROLASE 26S proteasome non-ATPase regulatory subunit 4,Ubiquitin
2ayn2ayn Structure of USP14, a proteasome-associated deubiquitinating enzyme HYDROLASE deubiquitinating enzymes, DUB, USP14, proteasome, enzyme mechanism, HYDROLASE Ubiquitin carboxyl-terminal hydrolase 14
2ayo2ayo Structure of USP14 bound to ubquitin aldehyde HYDROLASE deubiquitinating enzyme, DUB, USP14, proteasome, enzyme mechanism, HYDROLASE Ubiquitin carboxyl-terminal hydrolase 14,Ubiquitin
2dzn2dzn Crystal structure analysis of yeast Nas6p complexed with the proteasome subunit, rpt3 PROTEIN BINDING ankyrin repeats, a-helical domain, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI, PROTEIN BINDING 26S protease regulatory subunit 6B homolog,Probable 26S proteasome regulatory subunit p28
2jy62jy6 Solution structure of the complex of ubiquitin and ubiquilin 1 UBA domain SIGNALING PROTEIN Ubiquilin, UBA, Ubiquitin, complex, Alternative splicing, Cytoplasm, Nucleus, Phosphoprotein, Proteasome, SIGNALING PROTEIN Ubiquitin protein,Ubiquilin-1
2ku12ku1 Dynamic Regulation of Archaeal Proteasome Gate Opening as Studied by TROSY-NMR HYDROLASE proteasome, proteolysis, gating residues, Cytoplasm, Hydrolase, Protease, Threonine protease Proteasome subunit alpha
2o952o95 Crystal Structure of the Metal-Free Dimeric Human Mov34 MPN domain (residues 1-186) UNKNOWN FUNCTION PSMD7, 26S Proteasome, Mov34, Jab1/MPN, metal-free dimer, UNKNOWN FUNCTION 26S proteasome non-ATPase regulatory subunit 7
2wg52wg5 PROTEASOME-ACTIVATING NUCLEOTIDASE (PAN) N-DOMAIN (57-134) FROM ARCHAEOGLOBUS FULGIDUS FUSED TO GCN4 TRANSCRIPTION,HYDROLASE TRANSCRIPTION HYDROLASE COMPLEX, NUCLEOTIDE-BINDING, SUBSTRATE RECOGNITION, COILED COIL, AAA PROTEIN, CHAPERONE ACTIVITY, ATPASE, OB FOLD, CYTOPLASM, PROTEASOME, ATP-BINDING AMINO-ACID BIOSYNTHESIS, TRANSCRIPTION, TRANSCRIPTION REGULATION, NUCLEUS, DNA-BINDING, ACTIVATOR, PHOSPHOPROTEIN, TRANSCRIPTION,HYDROLASE GENERAL CONTROL PROTEIN GCN4, PROTEASOME-ACTIVATING NUCLEOTIDASE
2z592z59 Complex Structures of Mouse Rpn13 (22-130aa) and ubiquitin PROTEIN TRANSPORT Proteasome, NMR, PH domain, PROTEIN TRANSPORT Protein ADRM1,Ubiquitin
2z5b2z5b Crystal Structure of a Novel Chaperone Complex for Yeast 20S Proteasome Assembly CHAPERONE PROTEASOME, Chaperone, S. cerevisiae Uncharacterized protein YLR021W,Protein YPL144W
2z5c2z5c Crystal Structure of a Novel Chaperone Complex for Yeast 20S Proteasome Assembly CHAPERONE/HYDROLASE PROTEASOME, Chaperone, S. cerevisiae, CHAPERONE/HYDROLASE COMPLEX Uncharacterized protein YLR021W,Protein YPL144W,Proteasome component PUP2
2z5e2z5e Crystal Structure of Proteasome Assembling Chaperone 3 CHAPERONE BETA SANDWICH, HOMODIMER, PROTEASOME, CHAPERONE Proteasome Assembling Chaperone 3
3aji3aji Structure of G alt CHAPERONE/PROTEIN BINDING Gankyrin, S6 atpase, p-benzoyl-L-phenylalanine, pbpa, amber suppression, Structural Genomics, RIKEN Structural Genomics/Proteomics Initiative, RSGI, CHAPERONE-PROTEIN BINDING complex Proteasome (Prosome, macropain) 26S subunit, ATPase, 4,26S proteasome non-ATPase regulatory subunit 10
3h433h43 N-terminal domain of the proteasome-activating nucleotidase of Methanocaldococcus jannaschii HYDROLASE Proteasome, regulatory particle, nucleosidase, ATP-binding, Cytoplasm, Nucleotide-binding, HYDROLASE Proteasome-activating nucleotidase
3h4p3h4p Proteasome 20S core particle from Methanocaldococcus jannaschii HYDROLASE 20S, Proteasome, core particle, Cytoplasm, Hydrolase, Protease, Threonine protease Proteasome subunit alpha,Proteasome subunit beta
3ihr3ihr Crystal Structure of Uch37 HYDROLASE Center for Eukaryotic Structural Genomics, Uch37, UCH-L5, ubiquitin hydrolase, Homo sapiens, ubiquitin, proteasome, ino80, smad7, rpn13, PSI, Protein structure initiative, CESG, structural genomics, Alternative splicing, Hydrolase, Polymorphism, Protease, Thiol protease, Ubl conjugation pathway Ubiquitin carboxyl-terminal hydrolase isozyme L5
3m913m91 Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa HYDROLASE REGULATOR coil coil alpha helix, ATP-binding, Chaperone, Nucleotide-binding, Proteasome, S-nitrosylation, Virulence, Isopeptide bond, Ubl conjugation pathway, HYDROLASE REGULATOR Proteasome-associated ATPase,Prokaryotic ubiquitin-like protein pup
3m9d3m9d Crystal structure of the prokaryotic ubiquintin-like protein Pup complexed with the hexameric proteasomal ATPase Mpa which includes the amino terminal coiled coil domain and the inter domain CHAPERONE alpha helix coil coil, 5 beta-strand barrel, ATP-binding, Chaperone, Nucleotide-binding, Proteasome, S-nitrosylation, Virulence, Isopeptide bond, Ubl conjugation pathway Proteasome-associated ATPase,Prokaryotic ubiquitin-like protein pup
3m9h3m9h Crystal structure of the amino terminal coiled coil domain of the Mycobacterium tuberculosis proteasomal ATPase Mpa CHAPERONE four helix antiparallel bundle, ATP-binding, Chaperone, Nucleotide-binding, Proteasome, S-nitrosylation, Virulence Proteasome-associated ATPase
3mi03mi0 Crystal Structure of Mycobacterium Tuberculosis Proteasome at 2.2 A HYDROLASE Enzyme Inhibitors, Lactones, Proteasome Endopeptidase Complex, Mycobacterium tuberculosis, HYDROLASE Proteasome subunit alpha,Proteasome subunit beta
3q5w3q5w Structure of proteasome tether CELL CYCLE PROTEASOME, TETHER, 26S, CHROMOSOME, CELL CYCLE, dimer, novel fold Protein cut8

Warning!! Chain names and residue indexes may have been reassigned and differ from the original PDB file (more info)