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DSIR: Supplementary informations


Vert JP, Foveau N, Lajaunie C, Vandenbrouck Y. An accurate and interpretable model for siRNA efficacy prediction.BMC Bioinformatics. 2006 Nov 30;7(1):520.

Please cite this paper, if you use DSIR

Additional data

We built a linear model on a set of siRNA provided by Huesken et al. (Nat. Biotechnol., 23(8):995-1001, 2005. Trained on the training set of 2182 sequences below, it reaches a Pearson correlation coefficient of 0.67 on the test set of 249 siRNA available below. The model implemented on this server has been trained on the training and test set pooled together, therefore its weights (available below) differ slightly from the weights published in the reference article.

The set of siRNA experimentally validated for computational model assessment published in Filhol O, Ciais D, Lajaunie C, Charbonnier P, Foveau N, et al. (2012) DSIR: Assessing the Design of Highly Potent siRNA by Testing a Set of Cancer-Relevant Target Genes. PLoS ONE 7(10): e48057.

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