Cancer drivers are any genomic variations that contribute to the progress of a tumor. Nearly all known cancer drivers are located in the 2% coding fraction of the human genome. However the remaining 98% contains thousands of non-coding RNA (ncRNA) genes regulatory DNA elements that control gene expression, wich is a predominant function in known cancer drivers. This project aims at modelling functional constraints acting on the non-coding genome to derive a scoring system for non-coding mutations that we use for the discovery of novel cancer drivers.
The 98 Driver Project is funded by a french ITMO Cancer "Systems Biology" grant.
Authors: Jia Li, Marie-Anne Poursat, Damien Drubay, Arnaud Motz, Zohra Saci, Antonin Morillon, Stefan Michiels, Daniel Gautheret